SPL (Systems Pharmacology Lab, Prof. Wankyu Kim) aims to develop an innovative approach towards precision medicine. We are interested in applying both computational and experimental approaches in order to gain systems level understanding of diseases and drug mode-of-action (MoA), facilitating the infamously difficult process of drug discovery & development. To this end, our work typically involves large-scale analysis of biological big data such as genome, transcriptome, and drug screening data.

Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer

Drug repositioning for glioblastoma based on large-scale drug-induced transcriptional signatures

Connectivity Map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer

Oncogene. 2020 May;40(10):1921

Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data

CDRgator: An integrative navigator of Cancer Drug Resistance Gene signatures

CSgator: An integrated web platform for Compound Set analysis